A Synthetic Biology Approach For a Vaccine Platform Against Known and Newly Emerging 1 Serotypes of Bluetongue
نویسندگان
چکیده
منابع مشابه
A Synthetic Biology Approach For a Vaccine Platform Against Known and Newly Emerging 1 Serotypes of Bluetongue Virus 2 3 Sandro
*Corresponding Author 14 Massimo Palmarini 15 MRC University of Glasgow Centre for Virus Research 16 464 Bearsden Road 17 Glasgow G61 1QH 18 Scotland (UK) 19 Tel: +44 (0)141-33
متن کاملA Synthetic Biology Approach for a Vaccine Platform against Known and Newly Emerging Serotypes of Bluetongue Virus
UNLABELLED Bluetongue is one of the major infectious diseases of ruminants and is caused by bluetongue virus (BTV), an arbovirus existing in nature in at least 26 distinct serotypes. Here, we describe the development of a vaccine platform for BTV. The advent of synthetic biology approaches and the development of reverse genetics systems has allowed the rapid and reliable design and production o...
متن کاملEvaluation of cross-protection of bluetongue virus serotype 4 with other serotypes in sheep.
Bluetongue (BT) is a non-contagious disease of sheep and other domestic and wild ruminants caused by the bluetongue virus (BTV). Currently 26 serotypes of the virus have been identified. In South Africa, 22 serotypes have been identified and BT is controlled mainly by annual vaccinations using a freeze-dried live attenuated polyvalent BTV vaccine. The vaccine is constituted of 15 BTV serotypes ...
متن کاملIn silico Analysis of Pasteurella multocida PlpE Protein Epitopes As Novel Subunit Vaccine Candidates
Background: Pasteurella multocida is a Gram-negative, non-motile, non-spore forming, and aerobic/anaerobic cocobacillus known as the causative agent of human and animal diseases. Humans can often be affected by cat scratch or bite, which may lead to soft tissue infections and in rare cases to bacteremia and septicemia. Commercial vaccines against this agent include inactivated, live attenuated,...
متن کاملSerological Detection of FMD Serotypes by New Prepared Innovative Recombinant Hepta-Epitopic Peptide
Background: Foot-and-mouth disease (FMD) is a highly contagious and economically important disease that affects cloven-hoofed animals worldwide. In recent years, a series of outbreaks of FMD have occurred in many countries. Recombinant protein synthesis incorporating protective B- and T-cell epitopes are candidates for new safer and more effective (FMD) vaccines that have potential to provide p...
متن کامل